Research Support from amfAR Documents First Case of Child Cured of HIV
amfAR's new pediatric cure research collaboratory pays dividends
within months of being established
NEW YORK, March 3, 2013 - Dr. Deborah Persaud of Johns Hopkins University today described the first
documented case of a child being cured of HIV. The landmark findings were announced at the 2013 Conference on Retroviruses and
Opportunistic Infections in Atlanta, GA.
Dr. Persaud, an amfAR grantee, detailed the case of a two-year-old child in Mississippi diagnosed with HIV at birth and
immediately put on antiretroviral therapy. At 18 months, the child ceased taking antiretrovirals and was lost to follow-up. When
brought back into care at 23 months, despite being off treatment for five months, the child was found to have an undetectable viral
load. A battery of subsequent highly sensitive tests confirmed the absence of HIV.
Confirmation of the cure was made possible by a grant the Foundation awarded to Dr. Persaud and Dr. Katherine Luzuriaga
of the University of Massachusetts in September 2012. The grant allowed Drs. Persaud and Luzuriaga to establish a research
collaboratory to explore and document possible pediatric HIV cure cases. The collaboratory includes renowned researchers
Drs. Stephen Spector and Doug Richman at the University of California, San Diego; Dr. Frank Maldarelli at the National
Cancer Institute; and Dr. Tae-Wook Chun at the National Institute of Allergy and Infectious Diseases.
"The child's pediatrician in Mississippi was aware of the work we were doing, and quickly notified our team as soon as this
young patient's case came to her attention," said Dr. Rowena Johnston, amfAR vice president and director of research. "Because the
collaboratory was already in place, the researchers were able to mobilize immediately and perform the tests necessary to
determine if this was in fact a case of a child being cured."
According to Dr. Persaud, comprehensive tests have confirmed beyond doubt that both mother and child were HIV positive when
the child was born, and today no signs of HIV infection in the child can be detected by the most sensitive means available.
The only other documented case of an HIV cure to date remains that of Timothy Brown, the so-called "Berlin patient."
In 2006, while on treatment for HIV, Mr. Brown was diagnosed with leukemia. His physician was able to treat his leukemia with a
stem-cell transplant from a person who was born with a genetic mutation causing immunity to HIV infection. Following the
transplant, Mr. Brown was able to stop HIV treatment without experiencing a return of his HIV disease.
This new case points to the tantalizing possibility that different populations of HIV-positive people might be cured in
different ways. While Mr. Brown's case was the outcome of a complex, high-risk, and expensive series of procedures, this new case
appears to have been the direct result of a comparatively inexpensive course of antiretroviral therapy.
"Given that this cure appears to have been achieved by antiretroviral therapy alone," said Dr. Johnston, "it is also
imperative that we learn more about a newborn's immune system, how it differs from an adult's, and what factors made it possible
for the child to be cured."
The Mississippi case also underscores the importance of identifying HIV-positive pregnant women, expanding access
to treatment regimens than can prevent mother-to-child transmission, and of immediately putting infants on antiretroviral
therapy in the event that they are born HIV positive.
"We are proud to have played a leading role in bringing this first pediatric HIV cure to light," said amfAR CEO Kevin
Robert Frost. "The case is a startling reminder that a cure for HIV could come in ways we never anticipated, and we hope this is the
first of many children cured of HIV in the months and years to come."
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Source: amfAR, The Foundation for AIDS Research
About amfAR
amfAR, The Foundation for AIDS Research, is one of the world's leading nonprofit organizations dedicated to the support of AIDS research,
HIV prevention, treatment education, and the advocacy of sound AIDS-related public policy. Since 1985, amfAR has invested more than
$366 million in its programs and has awarded grants to more than 2,000 research teams worldwide. www.amfar.org
MEDIA CONTACTS:
David Smith
amfAR, The Foundation for AIDS Research
C: (908) 917-0654
"Reproduced with permission - amfAR, The Foundation for AIDS Research"
amfAR, The Foundation for AIDS Research
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