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Pregnancy Doubles HIV Risk in Men; First Trial of a Microbicide in Pregnant Women:
New Research Presented at International Microbicides Conference
PITTSBURGH, May 23 - Young women of reproductive-age are among those at greatest risk of
acquiring HIV, and several studies have suggested that during pregnancy women are even more susceptible to
infection. Now, a new study finds that pregnancy is a time when men also are at greater risk. In fact, their risk
doubles if their partner is both HIV-infected and pregnant.
The results were presented today at the International Microbicides Conference (M2010) in Pittsburgh,
along with findings of a pivotal study that is the first to ask whether using a microbicide during pregnancy is safe
for women and their babies.
Between 70 and 90 percent of all HIV infections in women are acquired through heterosexual
intercourse, and women are twice as likely as their male partners to acquire HIV during sex, due in part to
biological factors that make them more susceptible. Many women remain sexually active during pregnancy.
Although correct and consistent use of male condoms has been shown to prevent HIV infection, women often
cannot or do not wish to negotiate condom use with their male partners. And for many women, especially those
who wish to become pregnant, abstinence is not an option they can consider. Microbicides -- substances designed
to be applied topically on the inside of the rectum or vagina - are under active investigation as a method for
women to use to protect against HIV.
M2010 is taking place May 22-25 at Pittsburgh's David L. Lawrence Convention Center. Nearly 1,000
participants from 47 different countries are attending the meeting to hear about the latest developments in HIV
prevention research. Summaries of the two pregnancy-related studies are provided below.
Pregnancy doubles HIV risk in men, study finds
While a number of studies have shown that during pregnancy women are at increased risk of acquiring HIV from
an infected partner, a new study has found pregnancy is a time when men also are at greater risk - double the
risk, in fact. The study, which involved 3,321 couples in which one partner was HIV-infected and the other not,
is the first to show that a man in a relationship with an HIV-positive woman has a greater chance of becoming
infected while she is pregnant than when she is not.
Even after accounting for behavioral and other factors that usually contribute to HIV risk, the increased risk
associated with pregnancy remained. Biological changes that occur during pregnancy may make women more
infectious than they would be otherwise, explains Nelly Mugo, M.D., M.P.H., of the University of Nairobi &
Kenyatta National Hospital in Nairobi and the University of Washington in Seattle, who presented results of
the study on behalf of the Partners in Prevention HSV/HIV Transmission Study team. The study was conducted
in Botswana, Kenya, Rwanda, South Africa, Tanzania, Uganda and Zambia.
The researchers followed for up to two years 1,085 couples in which the male was infected and 2,236 couples
in which the female was infected to understand the different circumstances and determinants that may contribute to
HIV risk. During this time, 823 pregnancies took place, which allowed the researchers to look more closely at
the particular risk factors for HIV that occur during pregnancy and not. In their analysis, they found that
pregnancy was associated with increased risk of both female-to-male and male-to-female HIV transmission.
But for women with an HIV- infected partner, the study found that factors other than pregnancy also likely
contributed to this increased risk, such as sexual behavior. In men, however, the link between pregnancy
and HIV risk was much clearer, even after considering whether or not they had engaged in unprotected sex
or were circumcised. Measures of viral load and CD4 counts of the infected partner also had no bearing.
Increased female-to-male transmission of HIV during pregnancy may be due to physiological and immunological
changes that occur with pregnancy, the authors conclude, but more research will be needed to confirm this hypothesis.
Microbicide study in pregnant women takes a giant baby step for HIV prevention research
Results of the first study of a vaginal microbicide tested in pregnant women found only small amounts of drug
are absorbed into the bloodstream, amniotic fluid and umbilical cord blood. The study, which involved applying
a single dose of tenofovir gel hours before women gave birth by cesarean delivery, was conducted as a first step
toward determining if use of a vaginal microbicide during pregnancy is safe for women and their babies. The
findings support continuing with further studies of tenofovir gel in pregnant women, said Richard Beigi, M.D,
MSc., of the University of Pittsburgh and Magee-Womens Hospital of UPMC, who led the study for the
Microbicide Trials Network.
The active ingredient in tenofovir gel is an antiretroviral that is approved as an oral drug and used as part of the
standard HIV treatment regimen. Both research and clinical experience with the oral drug have indicated its use
is safe in HIV-infected women during pregnancy. In previous studies looking at the use of oral tenofovir for the
prevention of mother-to-child transmission of HIV, researchers found that low amounts of drug pass to the baby.
In the current trial, which involved healthy, uninfected pregnant women, the amount of drug found in umbilical
cord blood was 40-times lower than cord blood levels noted in these other studies after oral dosing, and the
amount that got absorbed into the maternal blood was at levels 50- to 100-times lower.
Young women of reproductive-age are among those who are at greatest risk of acquiring HIV. Pregnancy is a
time when they may be even more susceptible. Because no information has been available to know whether
using a candidate microbicide during pregnancy is safe, women who participate in clinical trials must use
contraception, and if women become pregnant, they must stop using study product- at a time when protection
may be needed the most. In this study, gel containing a single dose (40 mg) of tenofovir gel was applied in 16
healthy HIV-negative women approximately two hours before they gave birth by scheduled caesarean delivery.
Researchers took maternal blood samples before and up to 24 hours after the gel was applied and collected
samples of the amniotic fluid surrounding the baby, umbilical cord blood, placental tissue and uterine tissue. In
addition to finding very low levels of drug, the researchers also reported there were no serious side effects
attributed to the gel in either the mothers or their newborns. Based on these results, researchers now plan to
conduct a larger study of tenofovir gel in both pregnant and breastfeeding women.
More than 33 million people are living with HIV, more than two thirds of them in sub-Saharan Africa,
according to UNAIDS. The number of new infections continues to outstrip advances in treatment: For every two
people who begin treatment, five are newly infected. Globally, women account for half of all HIV infections,
and in sub-Saharan Africa, women comprise 60 percent of all infected adults. Young women are especially
vulnerable. In southern Africa women aged 15 to 24 are at least three times more likely than their male peers
to be infected with HIV. Meanwhile, men who have sex with men (MSM) bear the burden of the epidemic in the
United States and in other parts of the world, such as Europe, Latin America, Australia and New Zealand.
According to the U.S. Centers for Disease Control and Prevention, MSM of all races is the only risk group in the
United States in which new HIV infections are increasing. Black heterosexual women represent the third highest
risk group in the United States, after white MSM and black MSM, respectively
M2010 is the sixth biennial meeting of the International Microbicides Conference and marks the first
meeting in the United States since the 2000 inaugural gathering in Washington, D.C. Other previous meetings
have been in Antwerp, Belgium; London, England; Cape Town, South Africa; and New Delhi, India. Co-chairs
of this year's conference are Sharon Hillier, Ph.D., and Ian McGowan, M.D., Ph.D., both of the University of
Pittsburgh; and Gita Ramjee, Ph.D., of the Medical Research Council of South Africa. The scientific program
and other information about the meeting can be found at www.microbicides2010.org
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CONTACT:
Lisa Rossi
+1-412-641-8940
+1-412-916-3315 (mobile)
+1 (412) 325-6063/6064 (22-25 May)
RossiL@upmc.edu
Microbicides 2010 (International Conference on Microbicides)
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